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New Oxa‐Bridged Macrocycles
Author(s) -
Panten Johannes,
Surburg Horst,
Hölscher Bernd
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890081
Subject(s) - chemistry , process (computing) , combinatorial chemistry , biochemical engineering , nanotechnology , computer science , engineering , materials science , operating system
Abstract In creating new aroma molecules, the fragrance chemist can make use of several tools: receptor or combinatorial research as well as lead structure optimization of existing chemicals or substances from the natural pool. Sometimes, it is also possible to discover new structures via another way: the careful analysis of existing products and their production processes. In analyzing the production process of 1‐oxacyclohexadecan‐2‐one ( 6 ), we identified at least two new oxa‐bridged macrocyclic molecules. In continuation, these results inspired us to synthesize and evaluate more representatives with similar structures. In this contribution, presented at the RSC/SCI conference ‘ flavours & fragrances 2007 ’ in London, September 24–26, 2007, the synthesis and olfactory properties of several new oxa‐bridged macrocycles will be introduced and discussed.