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Alkaloids from Corydalis saxicola and Their Anti‐Hepatitis B Virus Activity
Author(s) -
Li HuiLiang,
Han Ting,
Liu RunHui,
Zhang Chuan,
Chen HaiSheng,
Zhang WeiDong
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890074
Subject(s) - chemistry , coptisine , corydalis , berberine , papaveraceae , alkaloid , traditional medicine , hbeag , chelidonium , stereochemistry , hbsag , hepatitis b virus , virus , biochemistry , biology , virology , palmatine , medicine , alternative medicine , traditional chinese medicine , pathology
Eight protoberberine‐type alkaloids and two indole alkaloids were isolated from the MeOH extracts of the herb Corydalis saxicola Bunting (Papaveraceae). Their structures were identified as dehydrocavidine ( 1 ), dehydroapocavidine ( 2 ), dehydroisoapocavidine ( 3 ), berberine ( 4 ), dehydroisocorypalmine ( 5 ), coptisine ( 6 ), tetradehydroscoulerine ( 7 ), berbinium ( 8 ), 1‐formyl‐5‐methoxy‐6‐methylindoline ( 9 ), and 1‐formyl‐2‐hydroxy‐5‐methoxy‐6‐methylindoline ( 10 ). Compounds 3, 9 , and 10 are new alkaloids. All compounds were tested for anti‐HBV activity against the 2.2.15 cell line in vitro. Dehydrocavidine ( 1 ), dehydroapocavidine ( 2 ), and dehydroisoapocavidine ( 3 ) exhibited inhibitory activity against HBsAg and HBeAg, but no cytotoxicity against the 2.2.15 cell line.