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Carboxamides Combining Favorable Olfactory Properties with Insect Repellency
Author(s) -
Gaudin JeanMarc,
Lander Thierry,
Nikolaenko Olga
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890058
Subject(s) - chemistry , deet , cockroach , isopropyl , insect repellent , insect , stereochemistry , combinatorial chemistry , organic chemistry , toxicology , botany , biology , ecology
By a simple methodology, we have synthesized 68 carboxamides, with structural analogy to the most efficient mosquitoes repellent DEET ( N , N ‐diethyl‐ m ‐toluamide, 9 ). Eight of them have very promising olfactory profiles. In addition, 34 carboxamides have been tested for their repellency properties against three breeds of cockroach; six of them are excellent in this domain. Two of these, the 2‐ethyl‐ N ‐isopropyl‐ N ‐methylbutanamide and N , N ‐diallyl‐2‐ethylbutanamide combine both the positive aspects, and are thus very good candidates for use in functional perfumery, and more particularly in home‐care formulations.