Premium
New Stemona Alkaloids from the Roots of Stemona sessilifolia
Author(s) -
Guo Aobo,
Jin Li,
Deng Zhiwei,
Cai Shaoqing,
Guo Shunxin,
Lin Wenhan
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890056
Subject(s) - chemistry , alkaloid , stereochemistry
From the roots of Stemona sessilifolia , three new stemona‐type alkaloids, namely stemosessifoine ( 1 ), isooxymaistemonine ( 2 ), and isomaistemonine ( 3 ), along with eight known alkaloids (bisdehydrostemoninine, isobisdehydrostemoninine, tuberostemonine, bisdehydrotuberostemonine, bisdehydrostemoninine, isobisdehydrostemoninine, stemoninine, and protostemonine), were isolated. Their structures were determined on the basis of extensive 2D‐NMR spectroscopic‐data analysis and by comparison with reported values in the literature. Compound 1 is a structurally unprecedented alkaloid, and it is depicted to be bioconverted from tuberostemonine as the precursor. Isooxymaistemonine ( 2 ) showed a positive effect on the human high‐density lipoprotein (HDL) receptor gene CD36 and LIMP II analogous‐1 (CLA‐1) at the dosage of 10 μg/ml.