Premium
New Hepatoprotective Coumarinolignoids from Mallotus apelta
Author(s) -
Xu JianFu,
Feng ZiMing,
Liu Jian,
Zhang PeiCheng
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890055
Subject(s) - chemistry , stereochemistry , traditional medicine , biochemistry , medicine
Three new coumarinolignoids, malloapelins A–C ( 1 – 3 , resp.), together with three known coumarinolignoids, cleomiscosin A ( 4 ), cleomiscosin B ( 5 ), and 5′‐demethylaquillochin ( 6 ), were isolated from the roots of Mallotus apelta Muell .‐ Arg . Compounds 1 – 6 are three pairs of regioisomeric coumarinolignoids. Their structures were elucidated on the basis of spectral evidence. Compounds 3 showed promising hepatoprotective activity against D ‐galactosamine‐induced toxicity in WB‐F344 rat hepatic epithelial stem‐like cells.