New Hepatoprotective Coumarinolignoids from Mallotus apelta

Three new coumarinolignoids, malloapelins A–C ( 1 – 3 , resp.), together with three known coumarinolignoids, cleomiscosin A ( 4 ), cleomiscosin B ( 5 ), and 5′‐demethylaquillochin ( 6 ), were isolated from the roots of Mallotus apelta Muell .‐ Arg . Compounds 1 – 6 are three pairs of regioisomeric coumarinolignoids. Their structures were elucidated on the basis of spectral evidence. Compounds 3 showed promising hepatoprotective activity against D ‐galactosamine‐induced toxicity in WB‐F344 rat hepatic epithelial stem‐like cells.