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Aldose‐Reductase‐ and Protein‐Glycation‐Inhibitory Principles from the Whole Plant of Duchesnea chrysantha
Author(s) -
Kim Jong Min,
Jang Dae Sik,
Lee Yun Mi,
Yoo Jeong Lim,
Kim Young Sook,
Kim JooHwan,
Kim Jin Sook
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890034
Subject(s) - ellagic acid , chemistry , ursolic acid , aldose reductase , glycation , inhibitory postsynaptic potential , quercetin , biochemistry , chromatography , antioxidant , polyphenol , enzyme , receptor , neuroscience , biology
Ellagic acid ( 1 ), 3,3′‐di‐ O ‐methylellagic acid ( 2 ), 3,3′,4‐tri‐ O ‐methylellagic acid ( 3 ), isovitexin ( 4 ), kaempferol 3‐ O ‐ β ‐ D ‐glucuronide methyl ester ( 5 ), quercetin 3‐ O ‐ α ‐ L ‐arabinopyranosyl‐(1→6)‐ β ‐ D ‐galactopyranoside ( 6 ), ursolic acid, pomolic acid, tormentic acid, euscaphic acid, euscaphic acid 28‐ O ‐ β ‐ D ‐glucopyranoside, and maslinic acid were isolated from the AcOEt‐ and BuOH‐soluble MeOH extract of Duchesnea chrysantha (whole plant). The isolates were subjected to in vitro bioassays to evaluate their inhibitory activity on rat‐lens aldose reductase (RLAR) and formation of advanced glycation end products (AGEs). The ellagic acids and flavonoids, compounds 1 – 6 , exhibited moderate inhibitory effects on RLAR. However, compounds 1 and 4 – 6 showed excellent inhibitory activities towards the formation of AGEs. This is the first report that 4 and 6 exhibit inhibitory activity towards AR and AGEs formation.