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Cytotoxic Alkaloids from the Bulbs of Fritillaria hupehensis
Author(s) -
Zhang YongHui,
Yang XiLiang,
Zhang Peng,
Zhou XueFeng,
Ruan HanLi,
Pi HuiFang,
Wu JiZhou,
Sun HanDong
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890023
Subject(s) - hela , phytochemical , chemistry , cytotoxic t cell , stereochemistry , positive control , cytotoxicity , traditional medicine , biochemistry , in vitro , medicine
Phytochemical investigation of the bulbs of Fritillaria hupehensis resulted in the isolation and structural elucidation of four new steroidal penta‐ and hexacyclic veratraman‐ and cevan‐based alkaloids, respectively, compounds 1 – 4 . They were obtained together with the known constituents ebeinine ( 5 ) and zhebeinine ( 6 ), which were isolated for the first time from this plant. The structures of the new isolates were established by spectroscopic and mass‐spectrometric analyses, in combination with chemical methods. All compounds were assayed for their cytotoxic effects towards HeLa and HepG2 cell lines. Compounds 1 and 2 showed significant inhibitory effects against both types of tumor cells, with IC 50 values in the range 2.52–0.23 μ M , similar as those for 5‐fluorouracil used as positive control.