Premium
A New Cytotoxic, Apoptosis‐Inducing Triterpenoid from the Rhizomes of Astilbe chinensis
Author(s) -
Zhang YiBin,
Peng XiaoYing,
Sun HongXiang
Publication year - 2008
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200890010
Subject(s) - hela , rhizome , chemistry , apoptosis , cytotoxicity , in vitro , k562 cells , cytotoxic t cell , stereochemistry , cancer cell , cell culture , biochemistry , growth inhibition , traditional medicine , cancer , biology , medicine , genetics
A new ursane‐based compound, astilbotriterpenic acid ( 1 ), was isolated from the rhizomes of Astilbe chinensis. Its structure was determined on the basis of chemical evidence and extensive spectroscopic methods, including 1D‐ and 2D‐NMR. The pentacyclic triterpenoid 1 was assayed for its i n vitro cytotoxicity against Bcap37, HeLa, HepG2, HO‐8910, K562, PAA, SGC7901, and P388 cancer cells, as well as for its apoptosis‐inducing activity in HeLa cells. Compound 1 was found to strongly inhibit tumor‐cell growth through induction of apoptosis and may, thus, be further evaluated as a novel chemotherapeutic agent.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom