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Benzophenones from Guignardia sp. IFB‐E028, an Endophyte on Hopea hainanensis
Author(s) -
Wang FengWu,
Ye YongHao,
Ding Hui,
Chen YunXi,
Tan RenXiang,
Song YongChun
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800353
Subject(s) - dipterocarpaceae , endophyte , benzophenone , chemistry , microbiology and biotechnology , biology , botany , stereochemistry , organic chemistry
The first natural S‐containing benzophenone dimer, named guignasulfide ( 3 ), was isolated from the culture of Guignardia sp. IFB‐E028, an endophytic fungus residing in healthy leaves of Hopea hainanensis. Its structure was determined through correlative analyses of its MS, 1D‐ and 2D‐NMR spectroscopic data. Two other known benzophenone derivatives, monomethylsulochrin and rhizoctonic acid ( 1 and 2 , resp.) were also isolated. Guignasulfide ( 3 ) was more active against the human liver cancer cell line HepG2 ( IC 50 value: 5.2±0.4 μ M ) than metabolites 1 and 2 ( IC 50 values: 63.5±0.6 and 60.2±0.5 μ M ); compounds 1 – 3 showed also moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with MIC values of 28.9±0.1, 60.2±0.4, and 42.9±0.5 μ M , respectively.