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Cycloartane Triterpenes from Dikamali, the Gum Resin of Gardenia gummifera and Gardenia lucida
Author(s) -
Kunert Olaf,
Sreekanth Gandhe,
Babu Gummadi Sreedhar,
Rao Belvotagi Venkat Rao Adavi,
Radhakishan Marupaka,
Kumar Bobbala Ravi,
Saf Robert,
Rao Achanta Venkata Narasimha Appa,
Schühly Wolfgang
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800339
Subject(s) - terpene , gardenia , chemistry , rubiaceae , stereochemistry , candida albicans , moiety , traditional medicine , staphylococcus aureus , flavonoid , botany , bacteria , organic chemistry , biology , traditional chinese medicine , genetics , medicine , alternative medicine , pathology , antioxidant
We report on the chemical investigation of dikamali gum, which is the resin of Gardenia gummifera and G. lucida (Rubiaceae). Six new cycloartane triterpenes, dikamaliartanes A–F ( 1 – 6 , resp.), together with a known flavonoid ( 7 ), were isolated and identified by NMR spectroscopy. All six cycloartanes are characterized by an open A ‐ring with a free COOH group at C(3). In four of them, the C‐atoms C(23)–C(27) form a 4‐methylfuran‐2‐yl moiety. Bacterial assays using Staphylococcus aureus, Candida albicans , and Mycobacteria have been carried out but did not reveal significant activity.