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Two New Cytotoxic Disulfated Holostane Glycosides from the Sea Cucumber Pentacta quadrangularis
Author(s) -
Han Hua,
Xu QiangZhi,
Yi YangHua,
Gong Wei,
Jiao BingHua
Publication year - 2010
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800324
Subject(s) - triterpene , chemistry , aglycone , sea cucumber , tetrasaccharide , glycoside , stereochemistry , saponin , two dimensional nuclear magnetic resonance spectroscopy , terpene , biochemistry , polysaccharide , medicine , ecology , alternative medicine , pathology , biology
Two new disulfated triterpene glycosides, pentactasides B and C ( 1 and 2 , resp.), were isolated from the sea cucumber Pentacta quadrangularis collected from the South China Sea. Their structures were elucidated by extensive spectral analysis (2D‐NMR and MS) and chemical methods. The compounds 1 and 2 possess the same tetrasaccharide moieties with two sulfated groups, but are different in the side chains of the triterpene aglycone. Pentactasides B and C ( 1 and 2 , resp.) showed significant cytotoxicities ( IC 50 0.09–2.30 μ M ) against different human tumor cell lines.