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Biological Evaluation of ent ‐Narciclasine, ent ‐Lycoricidine, and Certain Enantiomerically‐Related Congeners
Author(s) -
Matveenko Maria,
Banwell Martin G.,
Joffe Max,
Wan Soosan,
Fantino Emmanuelle
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800319
Subject(s) - chemistry , enantiomer , stereochemistry , cancer cell lines , cancer , cancer cell , biology , genetics
The non‐natural enantiomeric forms of narciclasine and lycoricidine ((−)‐ 1 and (−)‐ 2 , respectively), as well as congeners 3 – 6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13‐member human cancer cell‐line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)‐ 1 ) was found to be highly active in the same screens.