Synthesis and Anti‐HIV Activity of [ddN]‐[ddN] Dimers and Benzimidazole Nucleoside Dimers | Zendy

Li GuoRui | Zendy; Liu Jun | Zendy; Pan Qin | Zendy; Song ZhiBin | Zendy; Luo FengLing | Zendy; Wang ShaoRu | Zendy; Zhang XiaoLian | Zendy; Zhou Xiang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis and Anti‐HIV Activity of [ddN]‐[ddN] Dimers and Benzimidazole Nucleoside Dimers

Author(s) -

Li GuoRui,

Liu Jun,

Pan Qin,

Song ZhiBin,

Luo FengLing,

Wang ShaoRu,

Zhang XiaoLian,

Zhou Xiang

Publication year - 2009

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200800281

Subject(s) - benzimidazole , chemistry , human immunodeficiency virus (hiv) , nucleoside , nucleoside analogue , stereochemistry , virology , organic chemistry , medicine

In an attempt to combine the HIV‐inhibitory capacity of different 2′,3′‐dideoxynucleoside (ddN) analogs, we have designed and synthesized several dimers of [AZT]‐[AZT] and [AZT]‐[d4T]. In addition, we also synthesized the dimers of 1‐(1 H ‐benzimidazol‐1‐yl)‐1‐deoxy‐ β ‐ D ‐ribofuranose. The in vitro anti‐HIV activity of these compounds on a pseudotype virus, pNL4‐3.Luc.R‐E‐, in the 293T cells has been determined. Among these compounds, 2,2′‐(propane‐1,3‐diyl)bis[1‐( β ‐ D ‐ribofuranosyl)‐1 H ‐benzimidazole] ( 3 ) showed the highest anti‐HIV activity with similar effect as AZT.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research