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Biocatalytic Production of Acyclic Bis[bibenzyls] from Dihydroresveratrol by Crude Momordica charantia Peroxidase
Author(s) -
Xie ChunFeng,
Yuan HuiQing,
Qu JianBo,
Xing Jie,
Lü BeiBei,
Wang XiaoNing,
Ji Mei,
Lou HongXiang
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800229
Subject(s) - momordica , chemistry , peroxidase , in vitro , cancer cell lines , biotransformation , stereochemistry , enzyme , biochemistry , cancer , traditional medicine , cancer cell , medicine
Biotransformation of dihydroresveratrol by crude Momordica charantia peroxidase provided six new acyclic bis[bibenzyls] 1 – 6 . Their structures were established on the basis of NMR and MS analyses as C C, C O C , and C CH 2 C dimers of dihydroresveratrol. Compounds 1 – 6 were tested for antiproliferative activity against human prostate cancer PC3 cell line in vitro , and 2 and 6 were found to be more potent than the parent compound.