Biocatalytic Production of Acyclic Bis[bibenzyls] from Dihydroresveratrol by Crude  Momordica charantia  Peroxidase | Zendy

Xie ChunFeng | Zendy; Yuan HuiQing | Zendy; Qu JianBo | Zendy; Xing Jie | Zendy; Lü BeiBei | Zendy; Wang XiaoNing | Zendy; Ji Mei | Zendy; Lou HongXiang | Zendy

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Biocatalytic Production of Acyclic Bis[bibenzyls] from Dihydroresveratrol by Crude Momordica charantia Peroxidase

Author(s) -

Xie ChunFeng,

Yuan HuiQing,

Qu JianBo,

Xing Jie,

Lü BeiBei,

Wang XiaoNing,

Ji Mei,

Lou HongXiang

Publication year - 2009

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200800229

Subject(s) - momordica , chemistry , peroxidase , in vitro , cancer cell lines , biotransformation , stereochemistry , enzyme , biochemistry , cancer , traditional medicine , cancer cell , medicine

Biotransformation of dihydroresveratrol by crude Momordica charantia peroxidase provided six new acyclic bis[bibenzyls] 1 – 6 . Their structures were established on the basis of NMR and MS analyses as C C, C O C , and C CH 2 C dimers of dihydroresveratrol. Compounds 1 – 6 were tested for antiproliferative activity against human prostate cancer PC3 cell line in vitro , and 2 and 6 were found to be more potent than the parent compound.

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