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A New Antimicrobial Fatty Acid from the Calcareous Sponge Paragrantia cf. waguensis
Author(s) -
Tianero Ma. Diarey B.,
Hanif Novriyandi,
de Voogd Nicole J.,
van Soest Rob W. M.,
Tanaka Junichi
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800199
Subject(s) - chemistry , antimicrobial , sponge , staphylococcus aureus , escherichia coli , bacteria , cytotoxic t cell , stereochemistry , calcareous , minimum inhibitory concentration , fatty acid , thiophene , microbiology and biotechnology , biochemistry , organic chemistry , botany , biology , in vitro , gene , genetics
A new acetylenic fatty acid, 1 , has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT‐T2 rat bladder epithelial cells ( IC 50 >20 μg/ml), and antimicrobial activity with minimal‐inhibitory concentrations ( MIC ) of 64 and 128 μg/ml against Staphylococcus aureus and Escherichia coli , respectively.