A New Antimicrobial Fatty Acid from the Calcareous Sponge  Paragrantia  cf.  waguensis | Zendy

Tianero Ma. Diarey B. | Zendy; Hanif Novriyandi | Zendy; de Voogd Nicole J. | Zendy; van Soest Rob W. M. | Zendy; Tanaka Junichi | Zendy

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A New Antimicrobial Fatty Acid from the Calcareous Sponge Paragrantia cf. waguensis

Author(s) -

Tianero Ma. Diarey B.,

Hanif Novriyandi,

de Voogd Nicole J.,

van Soest Rob W. M.,

Tanaka Junichi

Publication year - 2009

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200800199

Subject(s) - chemistry , antimicrobial , sponge , staphylococcus aureus , escherichia coli , bacteria , cytotoxic t cell , stereochemistry , calcareous , minimum inhibitory concentration , fatty acid , thiophene , microbiology and biotechnology , biochemistry , organic chemistry , botany , biology , in vitro , gene , genetics

A new acetylenic fatty acid, 1 , has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT‐T2 rat bladder epithelial cells ( IC 50 >20 μg/ml), and antimicrobial activity with minimal‐inhibitory concentrations ( MIC ) of 64 and 128 μg/ml against Staphylococcus aureus and Escherichia coli , respectively.

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