Cationic Ester Porphyrins Cause High Levels of Phototoxicity in Tumor Cells and Induction of Apoptosis in HeLa Cells | Zendy

Wu Lin | Zendy; Yang Li | Zendy; Huang Jing | Zendy; Zhang Lixia | Zendy; Weng Xiaocheng | Zendy; Zhang Xiaolian | Zendy; Shen Chao | Zendy; Zhou Xiang | Zendy; Zheng Congyi | Zendy

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Cationic Ester Porphyrins Cause High Levels of Phototoxicity in Tumor Cells and Induction of Apoptosis in HeLa Cells

Author(s) -

Wu Lin,

Yang Li,

Huang Jing,

Zhang Lixia,

Weng Xiaocheng,

Zhang Xiaolian,

Shen Chao,

Zhou Xiang,

Zheng Congyi

Publication year - 2009

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200800173

Subject(s) - phototoxicity , chemistry , hela , propidium iodide , cationic polymerization , cytotoxicity , annexin , photodynamic therapy , apoptosis , staining , porphyrin , in vitro , cytotoxic t cell , photobleaching , microbiology and biotechnology , biochemistry , programmed cell death , fluorescence , organic chemistry , pathology , biology , physics , quantum mechanics , medicine

A series of cationic ester porphyrins are much more cytotoxic to tumor cells than photofrin, meso ‐tetrakis(1‐methylpyridinium‐4‐yl)porphyrin (TMPyP4), and cisplatin. The lowest IC 50 value for SGC7901 is ca. 6 n M in vitro with irradiation. These porphyrins also exhibited the most potent photo‐induced cytotoxicity without photobleaching. HeLa Cell apoptosis induced by cationic ester porphyrins after illumination was examined by flow cytometric analysis, staining assays with propidium iodide and annexin V FITC‐PI, and further confirmed by observing morphological changes in the cells. The result of this study indicates that these cationic ester porphyrins may be applied in photodynamic therapy (PDT) in the future.

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