Acylated Flavonol Bisdesmosides, Sinocrassosides A 3 –A 7  and B 3 , with Aminopeptidase N Inhibitory Activity from  Sinocrassula indica | Zendy

Morikawa Toshio | Zendy; Xie Haihui | Zendy; Wang Tao | Zendy; Matsuda Hisashi | Zendy; Yoshikawa Masayuki | Zendy

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Acylated Flavonol Bisdesmosides, Sinocrassosides A 3 –A 7 and B 3 , with Aminopeptidase N Inhibitory Activity from Sinocrassula indica

Author(s) -

Morikawa Toshio,

Xie Haihui,

Wang Tao,

Matsuda Hisashi,

Yoshikawa Masayuki

Publication year - 2009

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200800135

Subject(s) - chemistry , aminopeptidase , inhibitory postsynaptic potential , stereochemistry , curcumin , biochemistry , leucine , amino acid , neuroscience , biology

ix new acylated flavonol bisdesmosides, sinocrassosides A 3 , A 4 , A 5 , A 6 , A 7 , and B 3 ( 1 – 6 , resp.), were isolated from the MeOH extract of the whole plant of Sinocrassula indica. The structures of 1 – 6 were elucidated on the basis of chemical and physicochemical evidence. Among them, 2 and 6 which have an acyl group in the 3′′′‐position were found to show strong inhibitory effects on aminopeptidase N activity, which were stronger than that of curcumin.

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