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Acylated Flavonol Bisdesmosides, Sinocrassosides A 3 –A 7 and B 3 , with Aminopeptidase N Inhibitory Activity from Sinocrassula indica
Author(s) -
Morikawa Toshio,
Xie Haihui,
Wang Tao,
Matsuda Hisashi,
Yoshikawa Masayuki
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800135
Subject(s) - chemistry , aminopeptidase , inhibitory postsynaptic potential , stereochemistry , curcumin , biochemistry , leucine , amino acid , neuroscience , biology
ix new acylated flavonol bisdesmosides, sinocrassosides A 3 , A 4 , A 5 , A 6 , A 7 , and B 3 ( 1 – 6 , resp.), were isolated from the MeOH extract of the whole plant of Sinocrassula indica. The structures of 1 – 6 were elucidated on the basis of chemical and physicochemical evidence. Among them, 2 and 6 which have an acyl group in the 3′′′‐position were found to show strong inhibitory effects on aminopeptidase N activity, which were stronger than that of curcumin.