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Tucupentol, a Novel Mono‐tetrahydrofuranic Acetogenin from Annona montana , as a Potent Inhibitor of Mitochondrial Complex I
Author(s) -
Álvarez Colom Olga,
Neske Adriana,
Chahboune Nadia,
ZafraPolo M. Carmen,
Bardón Alicia
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800102
Subject(s) - acetogenin , chemistry , annonaceae , annona , annona muricata , stereochemistry , tetrahydrofuran , electron transport complex i , mitochondrion , biochemistry , botany , biology , solvent , respiratory chain
Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol ( 1 ) is a mono‐tetrahydrofuran‐pentahydroxy‐acetogenin. The inhibitory potency of tucupentol ( 1 ) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin‐A, cis ‐annonacin‐10‐one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8–5.4‐n M range.