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Cationic Porphyrins and Analogues as New DNA Topoisomerase I and II Inhibitors
Author(s) -
Shuai Li,
Wang Shaoru,
Zhang Lixia,
Fu Boqiao,
Zhou Xiang
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800083
Subject(s) - topoisomerase , cationic polymerization , chemistry , dna , in vitro , stereochemistry , covalent bond , enzyme , biochemistry , combinatorial chemistry , organic chemistry
A series of cationic porphyrins, and analogues such as cationic corroles and phthalocyanines were found to have biological activities towards topoisomerases I and II in vitro. Cationic porphyrins and phthalocyanines do not induce Topo I–DNA covalent complexes but inhibit topoisomerase I by direct binding to DNA, which limits topoisomerase I access to the DNA substrate. The lowest concentration where an inhibition effect is clearly visible of some derivatives is between 0.1 and 0.6 μ M . Furthermore, some complexes were found to inhibit the activity of the topoisomerase II.