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Nematicidal Cardenolides from Nerium indicum Mill .
Author(s) -
Wang XingBiao,
Li GuoHong,
Zheng LiJun,
Ji KaiYan,
Lü Hua,
Liu FangFang,
Dang LiZhi,
Mo MingHe,
Zhang KeQin
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200800011
Subject(s) - cardenolide , chemistry , bursaphelenchus xylophilus , bioassay , caenorhabditis elegans , fractionation , botany , traditional medicine , nematode , stereochemistry , biochemistry , chromatography , biology , glycoside , ecology , medicine , gene
Three nematicidal cardenolides were obtained from the AcOEt extract of Nerium indicum Mill. by bioassay‐guided fractionation. They include a new compound, 3 β ‐ O ‐( β ‐ D ‐diginosyl)‐14,15 α ‐dihydroxy‐5 α ‐card‐20(22)‐enolide ( 1 ), and two known compounds, uzarigenin ( 2 ) and cardenolide N‐1 ( 3 ). The median lethal concentrations ( LC 50 ) of compounds 1 – 3 against the nematodes Bursaphelenchus xylophilus, Panagrellus redivivus , and Caenorhabditis elegans at 72 h were 103.3, 49.0, and 45.4 mg l −1 , 257.0, 62.7, and 177.8 mg l −1 , and 242.9, 29.1, and 41.7 mg l −1 , respectively. This is the first report about the nematicidal activity of cardenolides.