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Three Novel, Structurally Unique Spirocyclic Alkaloids from the Halotolerant B‐17 Fungal Strain of Aspergillus variecolor
Author(s) -
Wang WenLiang,
Zhu TianJiao,
Tao HongWen,
Lu ZhenYu,
Fang YuChun,
Gu QianQun,
Zhu WeiMing
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790240
Subject(s) - halotolerance , chemistry , mycelium , hemiaminal , stereochemistry , strain (injury) , aspergillus , two dimensional nuclear magnetic resonance spectroscopy , microbiology and biotechnology , botany , bacteria , biology , genetics , anatomy
During our search for novel antitumor lead compounds from microorganisms living under extreme conditions, three novel alkaloids, variecolortides A–C ( 1 – 3 ), were isolated from the mycelia of the halotolerant fungal strain Aspergillus variecolor B‐17. The new compounds were found to share an unprecedented ‘spiro‐anthronopyranoid diketopiperazine’ structure, with a stable hemiaminal function, as corroborated by in‐depth NMR‐spectroscopic and mass‐spectrometric analyses, as well as by a single‐crystal X‐ray analysis of 1 . All compounds were shown to exhibit weak cytotoxic and antioxidant activities.