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Synthesis and DNA‐Cleavage Properties of Metal Complexes of 1,4,7,10‐Tetraazacyclododecane (Cyclen) Functionalized with a Pendant Benzocrown Ether
Author(s) -
Tan XinYu,
Zhang Ji,
Huang Yu,
Zhang Yu,
Zhou LiHong,
Jiang Ning,
Lin HongHui,
Wang Na,
Xia ChuanQin,
Yu XiaoQi
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790176
Subject(s) - cyclen , chemistry , cleavage (geology) , dna , ether , dna supercoil , ligand (biochemistry) , stereochemistry , polymer chemistry , combinatorial chemistry , organic chemistry , biochemistry , dna replication , receptor , geotechnical engineering , fracture (geology) , engineering
Abstract The synthesis and DNA‐cleavage properties of a series of novel mononuclear Zn II , Cu II , and Co II complexes 2 of a crown‐ether‐functionalized cyclen ligand is described. The Cu complex 2b displayed the highest catalytic activity towards pUC 19 DNA. The effects of reaction time, complex concentration, and pH were investigated, showing that 2b readily and efficiently converts supercoiled (type I ) plasmid DNA to nicked (type II) DNA under physiological conditions (37°, pH 7.4).