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Medicinal Chemistry Endeavors around the Phytocannabinoids
Author(s) -
Stern Eric,
Lambert Didier M.
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790149
Subject(s) - chemistry , cannabinoid , cannabinoid receptor , cannabis sativa , delta 9 tetrahydrocannabinol , cannabis , receptor , computational biology , pharmacology , biochemistry , botany , psychology , agonist , medicine , psychiatry , biology
Over the past 50 years, a considerable research in medicinal chemistry has been carried out around the natural constituents of Cannabis sativa L. Following the identification of Δ 9 ‐tetrahydrocannabinol (Δ 9 ‐THC) in 1964, critical chemical modifications, e.g. , variation of the side chain at C(3) and the opening of the tricyclic scaffold, have led to the characterization of potent and cannabinoid receptor subtype‐selective ligands. Those ligands that demonstrate high affinity for the cannabinoid receptors and good biological efficacy are still used as powerful pharmacological tools. This review summarizes past as well as recent developments in the structure–activity relationships of phytocannabinoids.