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A New Dihydroagarofuranoid Sesquiterpene from Microtropis fokienensis with Antituberculosis Activity
Author(s) -
Chou TsungHsien,
Chen IhSheng,
Sung PingJyun,
Peng ChienFang,
Shieh PoChuen,
Chen JihJung
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790139
Subject(s) - sesquiterpene , ethambutol , chemistry , mycobacterium tuberculosis , stereochemistry , in vitro , tuberculosis , biochemistry , antibiotics , rifampicin , medicine , pathology
A new dihydroagarofuran‐based sesquiterpene, 8‐acetoxymutangin ( 1 ), was isolated from the stems of Microtropis fokienensis , together with eight known compounds, including mutangin ( 2 ). Their structures were determined through in‐depth spectroscopic and mass‐spectrometric analyses. Among the isolated compounds, 1 exhibited potent in vitro antituberculosis activity, with an MIC value of 10.0 μg/ml against Mycobacterium tuberculosis 90‐221387, which is considerably better than that of mutangin ( 2 ). The activity of 1 lies in the same range as that of the clinic drug ethambutol ( MIC 6.25 μg/ml), despite completely different chemical structures, which indicates different modes of action.