Antibacterial Effects of a Monoporphyrinato Ytterbium(III) Complex and Its Free Components on  Staphylococcus aureus  as Determined by Stop‐Flow Microcalorimetry | Zendy

Hou AnXin | Zendy; Xue Zhi | Zendy; Liu Yi | Zendy; Qu SongSheng | Zendy; Wong WaiKwok | Zendy

Premium

Antibacterial Effects of a Monoporphyrinato Ytterbium(III) Complex and Its Free Components on Staphylococcus aureus as Determined by Stop‐Flow Microcalorimetry

Author(s) -

Hou AnXin,

Xue Zhi,

Liu Yi,

Qu SongSheng,

Wong WaiKwok

Publication year - 2007

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200790128

Subject(s) - isothermal microcalorimetry , porphyrin , chemistry , staphylococcus aureus , antibacterial activity , ytterbium , free base , nuclear chemistry , bacteria , biochemistry , organic chemistry , thermodynamics , biology , physics , genetics , salt (chemistry) , enthalpy , optoelectronics , doping

The antibacterial effect of Yb 3+ , the free porphyrin base 5,10,15,20‐tetrakis(4‐methoxyphenyl)porphyrin (H 2 TMP; 1 ), and the corresponding Yb 3+ porphyrinato complex [Yb III (TMP)(H 2 O) 3 ] + Cl − (Yb(TMP); 2 ) towards Staphylococcus aureus was investigated by stop‐flow microcalorimetry. By analyzing the obtained metabolic thermogenic curves, crucial parameters such as rate constant of bacterial growth ( k ), half inhibitory concentration ( IC 50 ), and generation time ( t G ) were determined. The antibacterial activities of the three compounds tested was 2 > 1 >Yb 3+ , with an IC 50 value of 273 mg/l for complex 2 . The Yb 3+ porphyrinato complex is proposed to benefit from synergetic effects of Yb 3+ and the free porphyrin 1 .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research