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Topoisomerase‐II‐Inhibitory Principles from the Stems of Spatholobus suberectus
Author(s) -
Han AhReum,
Park Hyen Joo,
Chen Daofeng,
Jang Dae Sik,
Kim HwaJung,
Lee Sang Kook,
Seo EunKyoung
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790127
Subject(s) - chemistry , catechin , topoisomerase , proanthocyanidin , stereochemistry , dna , biochemistry , polyphenol , antioxidant
Bioassay‐guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)‐catechin‐(4→8)‐(−)‐epicatechin) ( 1 ) and (+)‐catechin‐(4→8)‐(+)‐catechin‐(4→8)‐(−)‐epicatechin ( 2 ). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA‐topoisomerase‐II (Topo‐II)‐mediated KDNA decatenation, with IC 50 values of 22.5±2.3 and 21.9±2.2 n M , resp.