Topoisomerase‐II‐Inhibitory Principles from the Stems of  Spatholobus suberectus | Zendy

Han AhReum | Zendy; Park Hyen Joo | Zendy; Chen Daofeng | Zendy; Jang Dae Sik | Zendy; Kim HwaJung | Zendy; Lee Sang Kook | Zendy; Seo EunKyoung | Zendy

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Topoisomerase‐II‐Inhibitory Principles from the Stems of Spatholobus suberectus

Author(s) -

Han AhReum,

Park Hyen Joo,

Chen Daofeng,

Jang Dae Sik,

Kim HwaJung,

Lee Sang Kook,

Seo EunKyoung

Publication year - 2007

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200790127

Subject(s) - chemistry , catechin , topoisomerase , proanthocyanidin , stereochemistry , dna , biochemistry , polyphenol , antioxidant

Bioassay‐guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)‐catechin‐(4→8)‐(−)‐epicatechin) ( 1 ) and (+)‐catechin‐(4→8)‐(+)‐catechin‐(4→8)‐(−)‐epicatechin ( 2 ). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA‐topoisomerase‐II (Topo‐II)‐mediated KDNA decatenation, with IC 50 values of 22.5±2.3 and 21.9±2.2 n M , resp.

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