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Channel‐Forming Activity of Alamethicin: Effects of Covalent Tethering
Author(s) -
Woolley G. Andrew
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790113
Subject(s) - alamethicin , chemistry , tethering , covalent bond , ion channel , selectivity , biophysics , biochemistry , organic chemistry , microbiology and biotechnology , receptor , biology , catalysis
In this short review article, the effects of covalent tethering of alamethicin molecules on channel‐forming behavior are described. Broadly speaking, these chemical modifications have provided insight into all three aspects of channel behavior: the structure of the conducting state, the ion‐selectivity and ion‐permeation properties, and the voltage dependence. Each of these aspects are discussed in turn.