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Facts and Challenges in the Understanding of the Biosynthesis of Peptaibols by Trichoderma
Author(s) -
Kubicek Christian P.,
KomońZelazowska Monika,
Sándor Erzsébet,
Druzhinina Irina S.
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790097
Subject(s) - biosynthesis , computational biology , chemistry , biodiversity , mode of action , biology , biochemistry , ecology , gene
Species of the mitosporic filamentous fungal genus Trichoderma are prominent producers of both short (7–11 residues) and long (18–20 residues) peptaibols and peptaibiotics, which are thought to be involved in their interaction with other living systems. Numerous reviews are available regarding biodiversity, structure, and mode of action of these peptide derivatives, but little emphasis has been paid to the physiology and genetics of their formation. In this review article, we used the recent knowledge on biosynthesis and production of these components to speculate on some of the unknown points. We also highlight areas where further research is most urgently needed.