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Cytotoxic Cardenolides from Streptocaulon griffithii
Author(s) -
Zhang XiaoHui,
Zhu HuiLin,
Yu Qiang,
Xuan LiJiang
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790091
Subject(s) - cardenolide , hela , chemistry , cytotoxic t cell , in vitro , cell culture , pregnane , stereochemistry , cancer cell lines , a549 cell , glycoside , cancer cell , biochemistry , cancer , biology , genetics
A new cardenolide, 3‐ O ‐( β ‐glucopyranosyl)acovenosigenin A ( 1 ), was isolated from the roots of Streptocaulon griffithii , together with eight known cardenolides, compounds 2 – 9 . All compounds showed significant in vitro inhibition of the proliferation of the human gastrointestinal cancer cell line HGC‐27, with IC 50 values in the range of ca. 20–564 n M , taxol being used as positive control. Compound 1 was also found to be strongly cytotoxic against other human tumor cell lines, including A549, MCF‐7, and Hela cells.