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Benzoquinones from Ardisia japonica with Inhibitory Activity towards Human Protein Tyrosine Phosphatase 1B (PTP1B)
Author(s) -
Li YanFang,
Li Jia,
Shen Qiang,
Hu LiHong
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790086
Subject(s) - chemistry , in vitro , bioassay , fractionation , stereochemistry , protein tyrosine phosphatase , benzoquinone , enzyme , japonica , inhibitory postsynaptic potential , biochemistry , botany , chromatography , biology , genetics , neuroscience
From the whole plant of Ardisia japonica , four [1,4]benzoquinones were isolated by means of bioassay‐directed fractionation of the EtOH extract. Apart from the two known compounds maesanin ( 1 ) and its congener 2 , two new benzoquinones, i.e. , 5‐ethoxy‐2‐hydroxy‐3‐[(10 Z )‐pentadec‐10‐en‐1‐yl][1,4]benzoquinone ( 3 ) and 5‐ethoxy‐2‐hydroxy‐3‐[(8 Z )‐tridec‐8‐en‐1‐yl][1,4]benzoquinone ( 4 ), were identified. All compounds showed significant in vitro bioactivities against the PTP1B enzyme, with IC 50 values in the range of ca. 3–19 μ M .