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Medicinal Studies of Dimeric Phenols with Multiple Quaternary‐Ammonium Pendant Arms
Author(s) -
Tian Tian,
Weng XiaoCheng,
Song Yang,
Zhang LiXia,
Zhou Xiang,
Wang Yi
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790084
Subject(s) - chemistry , ammonium , dna , linker , acetylcholinesterase , transcription (linguistics) , in vitro , aché , stereochemistry , phenols , protein quaternary structure , combinatorial chemistry , biochemistry , organic chemistry , enzyme , gene , protein subunit , linguistics , philosophy , computer science , operating system
A series of biphenol‐derived quaternary ammonium salts, originally developed as DNA‐cross‐linking agents, and carrying either two ( i.e. , 1 ) or four ( i.e. , 2 ) net positive charges, were investigated for their in vitro DNA‐transcription‐ and acetylcholinesterase (AChE)‐inhibitory activities. The effects of charge and type of linker between the two phenolic residues were systematically investigated. Several compounds showed good activities in both tests, which makes them potential lead candidates for drug design.