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Cytotoxic Prenylated Phenolic Compounds from the Twig Bark of Garcinia xanthochymus
Author(s) -
Han QuanBin,
Qiao ChunFeng,
Song JingZheng,
Yang NianYun,
Cao XinWei,
Peng Yong,
Yang DaJian,
Chen ShiLin,
Xu HongXi
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790083
Subject(s) - chemistry , twig , garcinia , bark (sound) , stereochemistry , xanthone , prenylation , candida albicans , antifungal , two dimensional nuclear magnetic resonance spectroscopy , clusiaceae , traditional medicine , organic chemistry , botany , microbiology and biotechnology , biology , medicine , ecology , enzyme
Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1 – 3 , were isolated from the twig bark of Garcinia xanthochymus , along with the four known compounds 1,4,5,6‐tetrahydroxy‐7,8‐diprenylxanthone ( 4 ), 1,3,5,6‐tetrahydroxy‐4,7,8‐triprenylxanthone ( 5 ), garciniaxanthone E ( 6 ), and 6‐prenylapigenin ( 7 ). Their structures were elucidated by extensive spectroscopic analysis, including 1D‐ and 2D‐NMR as well as HR‐MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA‐MB‐435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.