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Synthesis and Cytotoxic Evaluation of Substituted Urea Derivatives as Inhibitors of Human‐Leukemia K562 Cells
Author(s) -
Cao Ping,
Huang XianFeng,
Ding Hui,
Ge HuiMing,
Li HuanQiu,
Ruan BanFeng,
Zhu HaiLiang
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790075
Subject(s) - chemistry , k562 cells , morpholine , cytotoxic t cell , urea , ring (chemistry) , leukemia , cell culture , cytotoxicity , stereochemistry , combinatorial chemistry , biochemistry , cell , in vitro , organic chemistry , medicine , genetics , biology
A series of substituted urea derivatives, compounds 1 – 14 , were synthesized and evaluated for their cytotoxic activities against the human‐leukemia K562 cell line. Two structurally simple compounds, 7 and 12 , both incorporating a morpholine ring, were found to be highly active, with IC 50 values of ca. 0.25 μ M .