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Chemical Etiology of Nucleic Acids: Aminopropyl Nucleic Acids (APNAs)
Author(s) -
Zhou Ding,
Froeyen Matheus,
Rozenski Jozef,
Van Aerschot Arthur,
Herdewijn Piet
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790061
Subject(s) - nucleic acid , chemistry , nucleic acid methods , biochemistry
Abstract Aminopropyl nucleic acids (APNAs) are constitutionally simple nucleic acid alternatives with one stereogenic center per nucleotide, and with the potential to hybridize with RNA and to exert catalytic functions. We have developed a protecting group strategy to synthesize APNAs, although in a not very efficient way. Isolation and purification of APNAs proved to be difficult. Their structures might be more suited to function as potential catalytic polymers than as information systems that may evolve into RNA.