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Labdane Diterpenoid Glycosides from Aster veitchianus
Author(s) -
Li ErWei,
Gao Xue,
Gao Kun,
Jia ZhongJian
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790046
Subject(s) - labdane , chemistry , bacillus subtilis , terpenoid , staphylococcus aureus , antibacterial activity , stereochemistry , acetylation , escherichia coli , abietane , glycoside , cytotoxic t cell , bacteria , biochemistry , in vitro , biology , genetics , gene
Four new labdane‐type rhamnopyranosides derived from 13‐epimanool, compounds 1 – 4 , with differently acetylated sugar moieties, were isolated from A. veitchianus. Their structures and absolute configurations were elucidated by chemical transformation, spectroscopic and mass‐spectrometric analyses (IR, 1D‐ and 2D‐NMR, HR‐ESI‐MS), as well as by single‐crystal X‐ray diffraction (compound 1 ). The isolates 2 – 4 were investigated for their cytotoxic properties against cultured human hepatoma (SMMC‐7721), ovarian neoplasm (HO‐8910), and leukemia (HL‐60) cells, and for their antibacterial activities against Escherichia coli, Bacillus subtilis , and Staphylococcus aureus.