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A New Cytotoxic Lanostane‐Type Triterpene Glycoside from the Sea Cucumber Holothuria impatiens
Author(s) -
Sun Peng,
Liu BaoShu,
Yi YangHua,
Li Ling,
Gui Min,
Tang HaiFeng,
Zhang DaZhi,
Zhang ShiLong
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790037
Subject(s) - lanostane , triterpene , sea cucumber , aglycone , glycoside , chemistry , stereochemistry , etoposide , biology , medicine , ecology , genetics , alternative medicine , pathology , chemotherapy
A new lanostane‐type triterpene glycoside, impatienside A ( 1 ), was isolated from the sea cucumber Holothuria impatiens , together with a structurally related, known compound, bivittoside D ( 2 ). Their structures were elucidated by in‐depth spectroscopic and mass‐spectrometric methods, including 1 H‐, 13 C‐, and 2D‐NMR, ESI‐MS, and HR‐ESI‐MS experiments, as well as by chemical evidence. Compounds 1 and 2 possess the same hexasaccharide moieties, but differ slightly in their holostane‐type triterpene aglycone. The two glycosides were found to exhibit in vitro cytotoxicities similar to or better than those of the potent anticancer drug etoposide (V‐16) against seven different human tumor cells, with IC 50 values of 0.37–2.75 μg/ml.