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Cytotoxic Withanolides from Physalis angulata L.
Author(s) -
He QingPing,
Ma Lei,
Luo JieYing,
He FuYuan,
Lou LiGuang,
Hu LiHong
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790036
Subject(s) - chemistry , cytotoxicity , stereochemistry , solanaceae , two dimensional nuclear magnetic resonance spectroscopy , dept , ic50 , physalis , cell culture , traditional medicine , hep g2 , in vitro , biochemistry , biology , medicine , gene , genetics
Four new withanolides, physagulins L–O ( 1 – 4 ), were isolated from the MeOH extract of the aerial parts of Physalis angulata L. (Solanaceae), together with seven known withanolides, compounds 5 – 11 . Their structures were determined by spectroscopic techniques, including 1 H‐, 13 C‐NMR (DEPT), and 2D‐NMR (HMBC, HMQC, 1 H, 1 H‐COSY, NOESY) experiments, as well as by HR‐MS. All eleven compounds were tested for their antiproliferative activities towards human colorectal‐carcinoma (HCT‐116) and human non‐small‐cell lung‐cancer (NCI‐H460) cells. Compound 5 exhibited the highest anticancer activity against the HCT‐116 cell line, with an IC 50 value of 1.64±0.06 μ M . Compound 9 exhibited the highest cytotoxicity towards the NCI‐H460 cell line, with an IC 50 value of 0.43±0.02 μ M ( Table 3 ).