A Water‐Soluble, Octacationic Zinc Phthalocyanine as Molecular Probe for Nucleic Acid Secondary Structure | Zendy

Zhang AnMing | Zendy; Huang Jing | Zendy; Weng XiaoCheng | Zendy; Li JinXi | Zendy; Ren LiGe | Zendy; Song ZhiBin | Zendy; Xiong XiaoQin | Zendy; Zhou Xiang | Zendy; Cao XiaoPing | Zendy; Zhou Yan | Zendy

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A Water‐Soluble, Octacationic Zinc Phthalocyanine as Molecular Probe for Nucleic Acid Secondary Structure

Author(s) -

Zhang AnMing,

Huang Jing,

Weng XiaoCheng,

Li JinXi,

Ren LiGe,

Song ZhiBin,

Xiong XiaoQin,

Zhou Xiang,

Cao XiaoPing,

Zhou Yan

Publication year - 2007

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200790026

Subject(s) - chemistry , singlet oxygen , zinc , guanine , phthalocyanine , oligonucleotide , dna , titration , nucleic acid , fluorescence , cleavage (geology) , gel electrophoresis , photochemistry , oxygen , biochemistry , inorganic chemistry , organic chemistry , nucleotide , physics , geotechnical engineering , quantum mechanics , fracture (geology) , engineering , gene

The interaction between CT‐DNA and the zinc phthalocyanine ZnPc ( 1 ) was studied by UV/VIS and fluorescence titration, as well as by thermal denaturation. ZnPc was found to strongly bind to CT‐DNA ( K app =7.35×10 5 M −1 ) in a non‐intercalative mode. The photosensitized cleavage of pBR322 DNA was found to efficiently proceed via singlet‐oxygen ( 1 O 2 ) production. Further, ZnPc ( 1 ) caused site‐specific scission of guanine (G) bases around the bulge of the hairpin oligonucleotides OD1 – OD3 , as clearly shown by gel‐electrophoresis experiments.

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