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Controlling the Association of Adamantyl‐Substituted Poly{ N ‐[tris(hydroxymethyl)methyl]acrylamide} and a β ‐Cyclodextrin/Epichlorohydrin Polymer by a Small Drug Molecule – Naproxen
Author(s) -
Mislovičová Danica,
Kogan Grigorij,
Gosselet Noëlle Martine,
Sébille Bernard,
Šoltés Ladislav
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790006
Subject(s) - chemistry , naproxen , epichlorohydrin , hydroxymethyl , cyclodextrin , acrylamide , polymer , adamantane , polymer chemistry , beta cyclodextrins , molecule , tris , organic chemistry , monomer , medicine , biochemistry , alternative medicine , pathology
Two polymeric substances, a poly{ N ‐[tris(hydroxymethyl)methyl]acrylamide} (THMMA) substituted with adamantyl moieties and a β ‐cyclodextrin/epichlorohydrin polycondensate, formed a host–guest type complex, which resulted in the gel formation upon mixing of these two compounds at appropriate conditions. Introduction of a drug molecule, i.e. , naproxen, that was able to fill the β ‐cyclodextrin cavities, thus expulsing adamantyl moieties, led to disruption of such association and inhibition of gel formation. The conditions required for the association of the two polymeric components and formation of the gel, as well as the dynamics of its inhibition by addition of naproxen was established. The procedure of using solutions of two associating polymers and an appropriate drug competitor can be used at targeted viscosupplementation.