Fatty Acid Synthase Inhibitors from  Geum japonicum   Thunb.  var.  chinense | Zendy

Liu Hongwei | Zendy; Li Jiankuan | Zendy; Zhao Wenhua | Zendy; Bao Li | Zendy; Song Xiaohong | Zendy; Xia Ying | Zendy; Wang Xue | Zendy; Zhang Chao | Zendy; Wang Xiaozhu | Zendy; Yao Xinsheng | Zendy; Li Ming | Zendy

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Fatty Acid Synthase Inhibitors from Geum japonicum Thunb. var. chinense

Author(s) -

Liu Hongwei,

Li Jiankuan,

Zhao Wenhua,

Bao Li,

Song Xiaohong,

Xia Ying,

Wang Xue,

Zhang Chao,

Wang Xiaozhu,

Yao Xinsheng,

Li Ming

Publication year - 2009

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200700462

Subject(s) - chemistry , ellagitannin , ellagic acid , fatty acid synthase , antioxidant , fractionation , biochemistry , fatty acid , terpenoid , chromatography , polyphenol

Bioassay‐guided fractionation of the MeOH extract of Geum japonicum Thunb. var. chinense using the fatty acid synthase inhibition assay led to the isolation of a new dimeric ellagitannin, gemin G ( 1 ), together with six known compounds, gemin A ( 2 ), casuarinin ( 3 ), pedunculagin ( 4 ), potentillin ( 5 ) , tellimagrandin II ( 6 ), and ellagic acid ( 7 ). Their structures were determined on the basis of spectroscopic analyses. Compounds 1 – 7 displayed strong inhibitory activities on fatty acid synthase with IC 50 values in the range of 0.21–41.4 μ M . Compounds 1 – 4 exhibited significant antioxidant activities higher than vitamin C in the ORAC assay. Compounds 1 and 2 also showed weak cytotoxic effects on BGC‐823 cell.

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