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Fatty Acid Synthase Inhibitors from Geum japonicum Thunb. var. chinense
Author(s) -
Liu Hongwei,
Li Jiankuan,
Zhao Wenhua,
Bao Li,
Song Xiaohong,
Xia Ying,
Wang Xue,
Zhang Chao,
Wang Xiaozhu,
Yao Xinsheng,
Li Ming
Publication year - 2009
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200700462
Subject(s) - chemistry , ellagitannin , ellagic acid , fatty acid synthase , antioxidant , fractionation , biochemistry , fatty acid , terpenoid , chromatography , polyphenol
Bioassay‐guided fractionation of the MeOH extract of Geum japonicum Thunb. var. chinense using the fatty acid synthase inhibition assay led to the isolation of a new dimeric ellagitannin, gemin G ( 1 ), together with six known compounds, gemin A ( 2 ), casuarinin ( 3 ), pedunculagin ( 4 ), potentillin ( 5 ) , tellimagrandin II ( 6 ), and ellagic acid ( 7 ). Their structures were determined on the basis of spectroscopic analyses. Compounds 1 – 7 displayed strong inhibitory activities on fatty acid synthase with IC 50 values in the range of 0.21–41.4 μ M . Compounds 1 – 4 exhibited significant antioxidant activities higher than vitamin C in the ORAC assay. Compounds 1 and 2 also showed weak cytotoxic effects on BGC‐823 cell.