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Cytotoxic Steroidal Saponins from Polygonatum punctatum
Author(s) -
Yang QingXiong,
Yang ChongRen
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690137
Subject(s) - chemistry , rhizome , saponin , stereochemistry , hela , glycoside , cytotoxic t cell , alpha (finance) , traditional medicine , biochemistry , in vitro , medicine , alternative medicine , pathology , construct validity , nursing , patient satisfaction
Four new steroidal saponins, polypunctosides A–D ( 1 – 4 , resp.), were isolated from the rhizomes of Polygonatum punctatum , together with five known steroidal saponins. On the basis of chemical and spectral evidence, the structures of the new saponins were established as (3 β ,23 S ,25 R )‐23‐( α ‐ L ‐arabinopyranosyloxy)spirost‐5‐en‐3‐yl 4‐ O ‐(6‐deoxy‐ α ‐ L ‐mannopyranosyl)‐ D ‐glucopyranoside ( 1 ), (3 β ,23 S ,25 R )‐23‐[(2‐ O ‐acetyl‐ α ‐ L ‐arabinopyranosyl)oxy]spirost‐5‐en‐3‐yl 4‐ O ‐(6‐deoxy‐ α ‐ L ‐mannopyranosyl)‐ D ‐glucopyranoside ( 2 ), (3 β ,23 S ,25 R )‐23‐[(3‐ O ‐acetyl‐ α ‐ L ‐arabinopyranosyl)oxy]spirost‐5‐en‐3‐yl 4‐ O ‐(6‐deoxy‐ α ‐ L ‐mannopyranosyl)‐ D ‐glucopyranoside ( 3 ), and (3 β ,23 S ,25 R )‐23‐[(4‐ O ‐acetyl‐ α ‐ L ‐arabinopyranosyl)oxy]spirost‐5‐en‐3‐yl 4‐ O ‐(6‐deoxy‐ α ‐ L ‐mannopyranosyl)‐ D ‐glucopyranoside ( 4 ). The cytotoxic activity of the isolated saponins was evaluated towards HeLa cells.