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Nitrilase and Its Application as a ‘Green’ Catalyst
Author(s) -
Singh Ram,
Sharma Rakesh,
Tewari Neetu,
Rawat Diwan S.
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690131
Subject(s) - stereocenter , nitrilase , chemistry , catalysis , carboxylic acid , enzyme , combinatorial chemistry , organic synthesis , hydrolase , ammonia , organic chemistry , stereochemistry , computational biology , enantioselective synthesis , biology
Hydrolase‐catalyzed reactions have been widely applied in organic synthesis. Nitrilases are an important class of hydrolase that converts naturally occurring, as well as xenobiotically derived, nitriles to the corresponding carboxylic acids and ammonia. Because of their inherent enantio‐ and regioselectivities and other benefits, nitrilases are attractive as ‘green’, mild, and selective catalysts for setting stereogenic centers in fine‐chemical synthesis and enantiospecific synthesis of a variety of carboxylic acid derivatives. In this review, the literature has been surveyed to provide a comprehensive coverage of the application of nitrilases in organic synthesis. Literature has also been cited to describe the isolation and/or characterization of nitrilases and related enzymes.