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Structure and Cytotoxicity of a New Lanostane‐Type Triterpene Glycoside from the Sea Cucumber Holothuria hilla
Author(s) -
Wu Jun,
Yi YangHua,
Tang HaiFeng,
Zou ZhengRong,
Wu HouMing
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690126
Subject(s) - triterpene , chemistry , lanostane , sea cucumber , cytotoxicity , glycoside , stereochemistry , uracil , terpene , thymine , two dimensional nuclear magnetic resonance spectroscopy , biochemistry , in vitro , biology , ecology , medicine , dna , alternative medicine , pathology
A new triterpene glycoside, hillaside C ( 1 ), was isolated from the sea cucumber Holothuria hilla Lesson , which is found in the South China Sea, and its structure has been elucidated by spectral analysis (ESI‐MS and NMR) and chemical transformations. Four known compounds, holothuria A, thymine, uracil, and cholesterol, were also obtained. Compound 1 exhibited significant cytotoxicity against eight human tumor cell lines (A‐549, MCF‐7, IA9, CAKI‐1, PC‐3, KB, KB‐VIN, and HCT‐8) with IC 50 values in the range of 0.15–3.20 μg/ml.