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Five New Steroidal Compounds from Ypsilandra thibetica
Author(s) -
Xie BaiBo,
Liu HaiYang,
Ni Wei,
Chen ChangXiang,
Lü Yang,
Wu Li,
Zheng QiTai
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690122
Subject(s) - chemistry , sapogenin , antifungal , stereochemistry , diol , bacteria , steroid , organic chemistry , biochemistry , microbiology and biotechnology , medicine , genetics , alternative medicine , pathology , hormone , biology
Five new steroids, including the four new steroidal saponins ypsilandroside B ( 1 ), ypsilandroside A ( 2 ), isoypsilandroside A ( 4 ), and isoypsilandroside B ( 5 ), as well as the new steroidal sapogenin isoypsilandrogenin ( 3 ), were isolated from the whole plant of Ypsilandra thibetica Franch . Their structures were determined on the basis of spectroscopic analyses, including extensive 2D‐NMR techniques. The structure and relative configuration of ypsilandroside B (=(3 β ,12 α ,25 R )‐3‐[( α ‐ L ‐rhamnopyranosyl‐(1→2)‐ β ‐ D ‐apiofuranosyl)oxy]spirost‐5‐ene‐12,27‐diol; 1 ) was unequivocally determined by single‐crystal X‐ray diffraction. The antifungal and antibacterial activities of 1 – 5 towards various types of fungi and bacteria are reported.