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Two New Taxanes from the Needles and Branches Bark of Taxus cuspidata
Author(s) -
Cao CongMei,
Zhang ManLi,
Wang YuFang,
Shi QingWen,
Yamada Teiko,
Kiyota Hiromasa
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690117
Subject(s) - chemistry , bark (sound) , taxane , glycoside , stereochemistry , botany , forestry , geography , biology , cancer , breast cancer , genetics
Two new taxanes were isolated from the MeOH extract of the needles and branches bark of the Japanese yew, Taxus cuspidata. The structures were established as (2 α ,5 α ,7 β ,9 α ,10 β ,13 α )‐5,10,13,20‐tetraacetoxytax‐11‐ene‐2,7,9‐triol ( 1 ) and (2 α ,5 α ,9 α ,10 β )‐2,9,10‐triacetoxy‐5‐[( β ‐ D ‐glucopyranosyl)oxy]‐3,11‐cyclotax‐11‐en‐13‐one ( 2 ) on the basis of in‐depth 1D‐ and 2D‐NMR analyses ( Tables 1 – 3, Fig. 1 ). Compound 2 is the first example of a transannular taxane glycoside isolated from a natural source.