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The Biochemistry of Drug Metabolism – An Introduction
Author(s) -
Testa Bernard,
Krämer Stefanie D.
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690111
Subject(s) - drug metabolism , metabolism , xenobiotic , drug , chemistry , enzyme , biochemistry , pharmacology , biology
This paper reviews the general principles and concepts underlying Drug and Xenobiotic Metabolism. Its five Chapters deal with: 1.1. Drugs and Xenobiotics, 1.2. What are Drug Disposition and Metabolism?, 1.3. Where does Drug Metabolism Occur?, 1.4. Consequences of Drug Metabolism ‐‐ An Overview, and 1.5. Drug Metabolism and Drug Discovery. This review is the first of seven Parts which will be published at intervals. The subsequent Parts will cover: 2. Redox Reactions and Their Enzymes, 3. Reactions of Hydrolysis and Their Enzymes, 4. Conjugation Reactions and Their Enzymes, 5. Metabolism and Bioactivity, 6. Inter‐Individual Factors Affecting Drug Metabolism, and 7. Intra‐Individual Factors Affecting Drug Metabolism.