Benzophenanthridine Alkaloids from  Zanthoxylum nitidum  ( Roxb .) DC, and Their Analgesic and Anti‐Inflammatory Activities | Zendy

Hu Jiang | Zendy; Zhang WeiDong | Zendy; Liu RunHui | Zendy; Zhang Chuan | Zendy; Shen YunHeng | Zendy; Li HuiLiang | Zendy; Liang MingJin | Zendy; Xu XiKe | Zendy

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Benzophenanthridine Alkaloids from Zanthoxylum nitidum ( Roxb .) DC, and Their Analgesic and Anti‐Inflammatory Activities

Author(s) -

Hu Jiang,

Zhang WeiDong,

Liu RunHui,

Zhang Chuan,

Shen YunHeng,

Li HuiLiang,

Liang MingJin,

Xu XiKe

Publication year - 2006

Publication title -

chemistry and biodiversity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.427

H-Index - 70

eISSN - 1612-1880

pISSN - 1612-1872

DOI - 10.1002/cbdv.200690108

Subject(s) - chemistry , analgesic , anti inflammatory , traditional medicine , pharmacology , analgesic agents , alkaloid , stereochemistry , medicine

Seven benzophenanthridine alkaloids, 1 – 7 , were isolated from the roots of Zanthoxylum nitidum. Among them, two novel alkaloids, named ( R )‐8‐[( R )‐1‐hydroxyethyl]dihydrochelerythrine ( 1 ) and 8‐methoxynorchelerythrine ( 2 ), were structurally identified as new compounds on the basis of the spectroscopic analysis. Bioactivity evaluation showed that nitidine ( 3 ), dihydrochelerythrine ( 4 ), oxyavicine ( 5 ), 8‐methoxychelerythrine ( 6 ), and 8‐hydroxydihydrochelerythrine ( 7 ) exhibit comparable analgesic and anti‐inflammatory effects as hydrocortisone.

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