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Nine New Dammarane Saponins from Gynostemma pentaphyllum
Author(s) -
Yin Feng,
Zhang YiNan,
Yang ZhengYi,
Hu LiHong
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690079
Subject(s) - gynostemma pentaphyllum , dammarane , chemistry , traditional medicine , lycium , triterpenoid , stereochemistry , triterpene , chromatography , extraction (chemistry) , medicine , alternative medicine , pathology
Nine new dammarane saponins, 1 – 9 , were isolated from the MeOH extract of the aerial part of Gynostemma pentaphyllum , an edible plant of the Cucurbitaceae family, that grows wildly in China. Their structures were elucidated by 1D‐ and 2D‐NMR analysis, as well as by chemical degradation. Aglycons 21,24‐cyclopentyldammar‐25‐ene of 6 and 7 , and 21,24‐cyclopentyldammarane of 8 and 9 , were novel. Compounds 1, 4 , and 8 showed moderate antitumor activities against stomach cancer cells SGC‐7901 and liver cancer cells BEL‐7402.