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New Chemical Constituents from the Endophyte Streptomyces Species LR4612 Cultivated on Maytenus hookeri
Author(s) -
Zhao PeiJi,
Li GuoHong,
Shen YueMao
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690036
Subject(s) - chemistry , formamide , endophyte , stereochemistry , chemical constituents , chemical structure , botany , amino acid , organic chemistry , biology , biochemistry , chromatography
From solid cultures of the biologically important endophyte Streptomyces species LR4612, cultivated on Maytenus hookeri , four new and two known compounds were isolated. The new compounds were identified as (2 S *,3 S *)‐5‐amino‐3‐hydroxy‐5‐oxopentan‐2‐yl 3‐(formylamino)‐2‐hydroxybenzoate ( 1 ), N ‐[(3 R *,4 R *)‐3‐amino‐3,4‐dihydro‐4‐methyl‐2,6‐dioxo‐2 H ,6 H ‐1,5‐benzodioxocin‐10‐yl]formamide ( 2 ), (5 β ,6 α )‐6,11‐dihydroxyeudesmane ( 3 ), and 5‐(6,7‐dihydroxy‐6‐methyloctyl)furan‐2(5 H )‐one ( 4 ); the known compounds were elucidated as sorbicillin ( 5 ) and N ‐acetyltyramine ( 6 ). The structures were established by HR‐ESI‐MS and in‐depth NMR analyses.