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A Novel Type of Membrane Based on Cholesteryl Phosphocholine, Cholesteryl Phosphate, or Sitosteryl Phosphate, and Dimyristoylglycerol
Author(s) -
Gotoh Mari,
Ribeiro Nigel,
Michels Bernard,
Elhabiri Mourad,
AlbrechtGary AnneMarie,
Yamashita Jun,
Hato Masakatsu,
Ourisson Guy,
Nakatani Yoichi
Publication year - 2006
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200690023
Subject(s) - chemistry , phosphate , vesicle , phosphocholine , membrane , cholesteryl ester , amphiphile , chromatography , differential scanning calorimetry , phospholipid , cholesterol , biochemistry , organic chemistry , phosphatidylcholine , lipoprotein , polymer , physics , copolymer , thermodynamics
Mixtures of amphiphilic cholesteryl phosphate (CP), sitosteryl phosphate (SP), or cholesteryl phosphocholine (CPC) with the nonphosphoryl diacyl lipid dimyristoylglycerol (DMG) or with cholesterol give self‐organized systems (giant vesicles) in a wide range of pH, as demonstrated by fluorescence microscopy, differential scanning calorimetry, and small‐angle X‐ray scattering. The water permeability of a 1 : 1 molar mixture of CPC and DMG was also measured by a stopped‐flow/light‐scattering method. The novel self‐organized systems are akin to natural eukaryotic ones, the only difference being the site of the phosphate‐containing head‐group, located on cholesterol instead of DMG. They might be present in some organisms not yet studied for the composition of their membranes.